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KMID : 0381219790110030051
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Journal of RIMSK
1979 Volume.11 No. 3 p.51 ~ p.56
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The Influences of Artificially Constricted Upper Airway or Increased Respiratory Dead Space on the Arterial Blood Grases in Rabbit
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Abstract
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Sudden changes in upper respiratory tract, either constriction of airway or increase of respiratory dead space, may affect the usual process of gas exchange in pulmonary-capillary system, thus mild to severe changes in arterial blood gases and cardiopulmonary function. will result. Therefore, the immediate restoration of an adequate airway in these patients may be lifesaving.
To understand the physiologic responses to the airway constriction or the increased. respiratory dead space the authors examined the changes of pulmonary function, vital signs and the arterial blood gases for one hour in two experimental groups, that is one following the addition of mechanical dead space and the other following the constriction of the upper airway artificially.
The results are as follows:
1. Blood gas analysis revealed adequate pulmonary ventilation and no significant physiologic changes in the mild airway-constricted group (about 1/3 of normal sized trachea) and the moderate deadspace-increased one (about 2 times of anatomical dead,space).
2. Airway resistance was slightly increased (3.5-7.5x) in all deadspace-increased groups, but markedly increased (80-140x) in all airway-constricted ones.
3. Physiologic changes were more acute and severe in airway-constricted groups than the deadspace-increased ones and this is probably due to the difference of the airway resistance.
4. Rabbits can tolerate the acute increase of mechanical dead space up to 2 times of anatomical dead space and the constriction of airway up to one third of normal diameter of the trachea without significant physiologic changes for about one hour.
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